You install Symantec Endpoint Protection clients on Microsoft Forefront TMG, Forefront Server Security for Sharepoint, or Forefront Server Security for Exchange Server. You need to configure the recommended exclusions.
Microsoft has an extensive list of recommended exclusions for each of these server products. Follow the appropriate link for your version of Microsoft Forefront. For more information on how to make these exclusions manually, please see How to add a Security Risk Exception in the Endpoint Protection Manager.
Microsoft ISA Server/Forefront TMG Considerations when using antivirus software on FF Edge Products: http://technet.microsoft.com/en-us/library/cc707727.aspx
Forefront Server Security for Sharepoint http://support.microsoft.com/default.aspx?scid=kb;EN-US;952167
Forefront Server Security for Exchange Server http://technet.microsoft.com/en-us/library/bb332342.aspx
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