You've recently installed or upgraded the Symantec Mail Security for Microsoft Exchange product. Since the upgrade, you are seeing Brightmail errors in your event log.
Event ID 514 "Error while reading conduit configuration from <sys vol> <drive>:\program files\symantec\smsmse\6.5\server\spamprevention\bmiconfig.xml" [If this is a x64 bit server, the path will be <drive>:\program files (x86)\symantec\smsmse\6.5\server\spamprevention\bmiconfig.xml
Symantec Premium AntiSpam registration failed on the server <server>.
Error retrieving Trusted Certificate location from configuration file.
You will need to run register to receive Brightmail rules..
Event ID: 514
190816196:1205 Error while reading conduit configuration from <sys vol>:\program files\symantec\smsmse\<ver>\server\spamprevention\bmiconfig.xml [<sys vol>:\program files (x86)\symantec\smsmse\<ver>\server\spamprevention\bmiconfig.xml
[Brightmail] (ERROR:7284.884):  Could not split the log file /path-to/base-dir/logs/conduit.log into the directory, log file name and extension.
 File path is malformed: "/path-to/base-dir/logs/conduit.log"
Failed to load Symantec Premium AntiSpam engine.
The installation path was not configured in the bmiconfig.xml file
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Trigger SMSMSE to fill in the proper values by completing the following procedure:
1. Open the regsitry editor (Start -> Run, Regedit).
2. Find the following registry folder :
32-bit systems (or version 7.9 and higher): HKEY_LOCAL_MACHINE\Software\Symantec\SMSMSE\<version>\Server\Components\SMTP\BMIConfigInit
64-bit systems (with version 7.5.x or lower): HKEY_LOCAL_MACHINE\Software\Wow6432Node\Symantec\SMSMSE\<version>\Server\Components\SMTP\BMIConfigInit
3. In the right pane, locate the value BMIConfigInit, right click it and choose Delete.
4. Restart the Symantec Mail Security for Microsoft Exchange service.
The bmiconfig.xml file should now contain the correct values, and allow registration of your Premium AntiSpam license.