Microsoft App-V version 5.0 SP2 or later is installed on the machine, and Dynamic Virtualization is enabled. When you launch Internet Explorer, Microsoft App-V generates Tamper Protection log entries in SEP 12.1 because it reads one or more SEP 12.1 .DLL files.
The following independent solutions/workarounds are available:
Disable Dynamic Virtualization within Microsoft App-V 5.0 Sp2 or later. For more information, please visit the following blog entry from Microsoft or reach out to Microsoft Technical Support: