Static route file /etc/sysconfig/network-scripts/route-eth1 with a rule to route traffic to the IP of a remote mail server via a gateway reachable only from Interface 2. The gateway might be 192.168.2.1.
In the above configuration, a Mail Proxy on Interface 2 will route traffic via Interface 2 and the receiving mail server would see a connection from 192.168.2.100.
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