Citrix XenApp uses a feature called “Virtual Memory Optimization” that rebases various DLLs of third party software, including DLLs belonging to Symantec Endpoint Protection (SEP). With XenApp 6.5 (or earlier) and SEP 14.x installed on the same system, ccSvcHst.exe crashes may be observed after applying the SDS update from May 15, 2018 (version 220.127.116.112).
SEP 14.0 or later with SDS update 18.104.22.1682 or later.
Citrix XenApp 6.5 or earlier.
Citrix XenApp virtual memory optimization is incompatible with SEP 14.0.
If ccSvcHst.exe crashes are observed on systems running Citrix XenApp and SEP 14.0, Symantec recommends one of the following solutions:
Configure Citrix XenApp to exclude SEP-related DLLs and EXEs from the virtual memory optimization feature, as mentioned on Citrix site: