After upgrading Symantec Endpoint Protection (SEP) client to version 14 with Application Control (AC) component installed, you are no longer able to launch your web-based (Microsoft ClickOnce) application.
IFS Applications 9
Microsoft Windows 10 64-bit
Symantec Endpoint Protection 14 installed with Application Control component
Microsoft ClickOnce (dfsvc.exe)
Microsoft's ClickOnce (dfsvc.exe) process causes an infinite loop in the Windows loader thread when Application Control (sysfer.dll) is injected into kernel32.