Patch fails to install with error code 2149842966.

Log Name:      Setup
Source:        Microsoft-Windows-WUSA
Event ID:      3
Task Category: None
Level:         Error
Description:
Windows update "Security Update for Windows (KB4489868)" could not be installed because of error 2149842966 "" (Command line: ""C:\Windows\system32\wusa.exe" "C:\Program Files\Altiris\Altiris Agent\Agents\SoftwareManagement\Software Delivery\{122EBF73-3C4D-FFDC-6B80-E8F849D1C6C7}\cache\windows10.0-kb4489868-x64-1803.msu" /quiet /norestart")
Event Xml:
<Event xmlns="http://schemas.microsoft.com/win/2004/08/events/event">
  <System>
    <Provider Name="Microsoft-Windows-WUSA" Guid="{09608C12-C1DA-4104-A6FE-B959CF57560A}" />
    <EventID>3</EventID>
    <Version>0</Version>
    <Level>2</Level>
    <Task>0</Task>
    <Opcode>0</Opcode>
    <Keywords>0x8000000000000000</Keywords>
    <TimeCreated SystemTime="2019-04-01T14:03:57.753975200Z" />
    <EventRecordID>40</EventRecordID>
    <Correlation />
    <Execution ProcessID="9052" ThreadID="6592" />
    <Channel>Setup</Channel>
    <Computer>COMPUTERNAME</Computer>
    <Security UserID="S-1-5-18" />
  </System>
  <EventData>
    <Data Name="UpdateTitle">"Security Update for Windows (KB4489868)"</Data>
    <Data Name="ErrorCode">2149842966</Data>
    <Data Name="ErrorString">
    </Data>
    <Data Name="CommandLine">"C:\Windows\system32\wusa.exe" "C:\Program Files\Altiris\Altiris Agent\Agents\SoftwareManagement\Software Delivery\{122EBF73-3C4D-FFDC-6B80-E8F849D1C6C7}\cache\windows10.0-kb4489868-x64-1803.msu" /quiet /norestart</Data>
  </EventData>
</Event>

"Command [STDeploy.exe package=""C:\ProgramData\Symantec\Patch\staging\deploy-package.zip"" sandboxesDir=""C:\ProgramData\Symantec\Patch"" logsDir=""c:\Program Files\Altiris\Altiris Agent\Agents\SoftwareManagement\Software Delivery\{122EBF73-3C4D-FFDC-6B80-E8F849D1C6C7}\cache"" patchStore=""c:\Program Files\Altiris\Altiris Agent\Agents\SoftwareManagement\Software Delivery\{122EBF73-3C4D-FFDC-6B80-E8F849D1C6C7}\cache""] executed with exit code 2149842966 (0x80240016)- 'Error 0x80240016 (No description available)'","Deployment Engine","AeXPatchDeployment.exe","7044","Errors"

ITMS 8.5

Windows Update Agent error.

Run a full backup of the System before proceeding.

1. Clear registry key values:

HKLM\Software\Policies\Microsoft\Windows\WindowsUpdate

2. Step 2. (Optional)
Recreate "NoAudoUpdate" Key if required to disabled Windows Update"

HKEY_LOCAL_MACHINE\Software\Policies\Microsoft\Windows\WindowsUpdate\AU
Key: NoAutoUpdate Value: 1