Any attempt to start the Altiris Agent results in the following error message:
Could not start the Altiris Agent service on Local Computer. Error 0x80004015: The class is configured to run as a security id different from the caller.
The issue seems to be related to computers that were under a certain GPO that restricted the SYSTEM account to start the Altiris Agent Service. Even after the GPO was disabled, the permissions were not set back to the default values for the SYSTEM account.
To view what the current security restrictions are on the service from a command window type the following: